RSE separator is made in Germany,is used to separate liquid- liquid-solid mixture,is characterized by large capacity, high separation factor and automatically discharging.POD separator is made in American,is characterized by large capacity, high extraction series (up to 4) and high yield. In the new process development of penicillin extraction，the series countercurrent extraction process was developed through combining the advantage of two types equipment. The process has the advantages of continuity and stablity, low labor intensity, good product quality and high yield etc..