Based on the relevant provisions "mine self-ignition orientation of coal seam must prepare the corresponding fire prevention measures ", took Changxing Mine as an example, the necessity of fire prevention measures were made. Combining Changxing Mine self-ignition orientation of geological conditions in the actual situation, as well as the coal mine safety regulations , standard of mine fire prevention (try out) and other relevant rules, regulations, the inhibitor for the spraying agent was given priority to grouting and auxiliary "monitoring and prediction and the inhibitor for the spraying agent + grouting" , comprehensive fire prevention technology and application was put forward.. Practice showed that the effective fire prevention measures ensured Changxing Mine fire prevention work smoothly, which provided a realistic basis for other spontaneous combustion danger of mine fire prevention work.