To study the reasonable position and surrounding rock stability of floor drainage roadway under the coupling effect of mining disturbance and high confined water, the engineering background of No. Ji15-33200 Face in Shajihai Mine was adopted in this paper. The floor failure range and floor drainage roadway layout horizon under the coupling effect were calculated theoretically. Numerical simulation studies were carried out for four different layout schemes. The plastic zone range, stress distribution and surrounding rock deformation were analyzed. Comparisons and verifications were performed with field monitoring data. Finally, the layout scheme with the floor drainage roadway vertically 22 m away from the working face and inward offset 15 m from the working face was determined to be optimal.