In order to solve the problems of low efficiency and poor selectivity of traditional coal flotation reagents in Wangzhuang Coal Preparation Plant, the application effect of new flotation reagents in coal preparation plant was explored. Through small flotation experiments and industrial tests, the flotation indexes of new reagents and traditional reagents under different conditions were compared and analyzed. The results show that the new flotation reagent can significantly improve the yield of clean coal, reduce the ash content of clean coal, optimize the flotation time and reagent dosage, improve the separation efficiency, reduce the production cost and reduce the environmental pollution.