Abstract： This paper provides a synthesis method of miraberon, using (R) -2- ((4-aminophenethyl) amino) -1-phenyleth-
anol hydrochloride and 2-aminothiazol-4-acetic acid as starting material, EDCI as condensation agent, concentrated hydrochloric acid to provide acidic environment, and ethanol-water as recrystallization solvent. The optimal process conditions are as follows n [(R) -2- ((4-aminophenethyl) amino) -1-phenylethanol hydrochloride]: n (2-aminothiazole-4-
acetic acid) =1:1.2, reaction temperature of 30 ℃, reaction time of 2 h, sodium hydroxide, pH, then recrystallized with 50% ethanol solution, the purity of 99.88% by HPLC test.
