In order to monitor the air volume and pressure of the main ventilator, the main ventilator of the east wing shaft of Hongda Mining Co., Ltd. was taken as the research object. Based on the quasi-steady flow theory, the static pressure difference method was used to measure the air volume and pressure of the main ventilator. The results show that the air volume of the main fan measured by static pressure difference method is 4 ~ 6 m3/s, the wind pressure is 800 ~ 2 800 Pa, and the maximum relative error is 2.8%, which can meet the relevant measurement requirements, meet the relevant standard performance, and has strong practicability.