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| Research progress of biocompatibility of hydroxyapatite / natural polymer composites |
| Liang Ye, Xiao Fengjuan, Li Xinxin, Yue lin, Li Song |
| School of Material Science and Engineering of Shijiazhuang Tiedao University, Hebei Province Key Laboratory of Traffic Engineering Materials, Shijiazhuang 050043, China |
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Abstract The current situation of research progress of hydroxyapatite(HA)/ natural polymer composites at home and abroad was reviewed, research progress of the biocompatibility of HA and a range of natural polymer composites was summarized. The key problems that exist in the research of the biological activity and biocompatibility of HA / natural polymer composites in vivo or in vitro were pointed out, and the research methods, development path and direction of improving the biocompatibility of composites were put forward.
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| [ 1 ] Liu D M, Troczynski T, Tseng W J. Aging effect on the phaseevolution of water-based sol-gel hydroxyapatite. Biomaterials. 2002,23(4 ):1 227-1 236.
[ 2 ] 郑 琪,奚廷斐,陈艳梅,等. 骨组织工程纳米复合支架及其生物学评价[ J ]. 中国组织工程研究与临床康复,2009,13(42 ):8 320.
[ 3 ] 陈 彦,于 博,李松建,等. 可注射壳聚糖/纳米羟基磷灰石/胶原复合材料的生物相容性实验研究[ J ]. 中国临床解剖学杂志,2011,29(6 ):689.
[ 4 ] Dhiman H K,Ray A R,Panda A K. Threedimensional chitosan scaffold-based MCF-7 cell culture for the determina-tion of the cytotoxicity of tamoxifen[ J ]. Biomaterials,2005,26:979-986.
[ 5 ] 王 菲,周 洪,郭昱成,等. 纳米羟基磷灰石/壳聚糖/聚丙交酯支架的体外生物相容性和成骨活性[ J ]. 中国组织工程研究,2014,18(8 ):1 198-1 204.
[ 6 ] 姚玉丽. 优选多组分纳米羟基磷灰石基复合材料及其生物相容性评价的实验研究[ D ]. 唐山:河北联合大学,2010.
[ 7 ] Itoh S,Yamaguchi I,Suzuki M,et al. Hydroxy-apatitecoated tendon chitosan tubes with adsorbed laminin peptides facilitate nerve regeneration in vivo[ J ]. Brain Research,2003,993:111-123.
[ 8 ] Muzzarelli R A A,Ramos V,Stanic V,et al. Osteogenesis promoted by calcium phosphate N, N-dicarboxymethyl chitosan. Carbohy-drate Polymers[ J ]. 1998,36:267-276.
[ 9 ] 唐晓军.天然羚基磷灰石/壳聚糖复合材料生物学特性的实验研究[ D ]. 北京:中国协和医科大学,2003.
[10] 周长忍,丁 珊,李立华. 可降解材料的制备及应用研究进展[ J ]. 中国创伤骨科杂志,2000,2(4 ):317- 319.
[11] 牛 林,邹 蕊,石福乔,等. 丝素蛋白-羟基磷灰石类骨质复合生物材料的生物相容性[ J ],西安交通大学学报(医学版),2011,32(5 ):629-631.
[12] 蔡 鑫,多孔型丝素蛋白/轻基磷灰石复合人工骨材料的相容性研究[ D ]. 苏州:苏州大学,2008.
[13] 范纯泉. 丝素蛋白/纳米轻基磷灰石复合材料的仿生制备及促进脊柱融合的实验研究[ D ]. 上海:第二军医大学,2010.
[14] 凌秀菊,龚兴厚,邱巧锐. 生物降解高分子/羟基磷灰石复合材料研究进展[ J ]. 高分子通报,2009(4 ):58-61.
[15] 殷丽华,韩雨芝,余红豆,等. 纳米羟基磷灰石复合支架材料生物性能的研究进展[ J ]. 华中科技大学学报(医学版), 2013,42(6 ):729-730.
[16] 姜 源,海洋胶原蛋白/羟基磷灰石复合骨修复材料的制备及其性能研究[ D ]. 上海:华东大学,2013.
[17] 刘 鹏,王 东,孙海钰,等. 胶原-纳米羟基磷灰石复合支架的细胞相容性[ J ]. 中国组织工程研究与临床康复,2011,15(42 ):7 831-7 834.
[18] 陈 彦,于 博,李松建. 可注射壳聚糖/纳米羟基磷灰石/胶原复合材料的生物相容性实验研究[ J ]. 中国临床解剖学杂志,2011,29(6 ):686-689.
[19] John A, Liu H, Ikada Y, et al. A trial to prepare biodegradable col-lagen-hydroxyapatite composites for bone repair[ J ]. J Biomater SciPolymer Edn,2001,12(6 ):689- 705.
[20] Roveri N,Falini G,Sidoti M C. Biologically inspired growth of hydroxyapatite nanocrystals inside self-assembled collagen fibers[ J ].Mater Sci Eng,2003,23:441- 446.
[21] 冯庆玲,崔福斋,张 伟. 纳米羟基磷灰石/胶原骨修复材料[ J ]. 中国医学科学院学报,2002,24(2 ):124-128.
[22] M atsumura Y. Poly(aminoacid) micelle nanocarriers in preclinical and clinical studies[ J ]. Adv Drug Deliv Rev, 2008,60(8 ):899-914.
[23] Liu Yonglei,Li Hong,Lu Guoyu,et al. The study on preparation and interface of n-HA/poly(amino acid )composite(n-HA )[ J ]. J Funct Mater,2010,41(4 ):566.
[24] 代震宇,蒋电明,李 军,等. 纳米羟基磷灰石/聚氨基酸复合材料体外成骨样细胞相容性评价[ J ]. 材料导报B:研究篇,2011,25(2 ):20-24.
[25] 杨晓波,裴福兴,严永刚,等. 聚氨基酸复合纳米羟基磷灰石的体内生物相容性实验研究[ J ]. 中国矫形外科杂志,2010,18(21 ):1 809-1 813.
[26] Williams S. Mechanical testing of a new biomaterial for potential use as a vasculargraft and articular cartilage replacement[ D ]. Atlanta: Georgia Institute of Technology,2006.
[27] Stamenkovic I,Aruffo A. Hyaluronic acid receptors[ J ]. Methods Enzymol,1994,245(3 ):195-216.
[28] Rosier R N,O'Keefe R J. Hyaluronic acid therapy[ J ]. Instr Course Lect,2000,49(4 ):495-502.
[29] Oksala O,Salo T,Tammi R,et al. Expression of proteoglycans and hyaluronan during wound healing[ J ]. J Histochem Cytochem[ J ]. 1995,43(2 ):125-135.
[30] 张彦聪,顾相伶,刘洪玲, 等. 人牙周膜细胞在透明质酸钠/纳米羟磷灰石支架上的黏附与生长[ J ]. 山东医药,2013,53(38 ):15-17.
[31] 戈进杰. 生物高分子材料及应用[ D ]. 北京:化学工业出版社,2002,48.
[32] A P Marques,Reis R L,Hunt J A. The biocompatibility of novel starch-bassed polymers and composites:in vitro studies. Biomaterials,2002(23 ):1 471.
[33] Sandra C M,Reis R L,Yvonne P B,et al. Biocompatibility testing of novel starch-based materials with potential application in orthopaedic:a preliminary study[ J ]. Biomaterials, 2001 (22):2 057.
[34] 关林波,但卫华,曾 容,等. 二明胶及其在生物材料中的应用[ J ]. 材料导报,2006(20 ):380-383.
[35] 孙永清,王佩玉,袁锡兰. 经基磷灰石人工骨与附加明胶复合体骨膜下植人的对比研究[ J ]. 山东医科大学学报, 1997,35(3 ):254-256.
[36] 张麒云,范存义.系统羟基磷灰石复合骨形态发生蛋白2人工骨的理论及其应用特征[ J ]. 中国组织工程研究及临床康复, 2007,11(26 ):5 207-5 210.
[37] 常 祺,黄昌林,黄 涛. 纳米级羟基磷灰石/骨形态发生蛋白复合物修复兔桡骨大段缺损及局部血管内皮细胞生长因子的表达[ J ]. 中国组织工程研究与临床康复,2011,15(12 ):2 113-2 116.
[38] Song J H, Kim J H, Park S, et al. Signaling responses of osteoblast cells to hydroxyapatite: the activation of ERK and SOX9[ J ]. J Bone Miner Metab,2008,26(2 ):138-142. |
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