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| Synthesis Progress of Erythromycin oxime |
| PAN Bing, SHEN Zhi-cheng, SUN Zhi-bo |
| CSPC Ouyi Pharmaceutical Limited Company, Shijiazhuang 050051, China |
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Abstract Erythromycin oxime, which is widely used and has broad market prospects, is the common intermediate of the second new generation erythromycin. The synthesis methods of erythromycin oxime were summarized as well as various methods were analyzed and compared. Aiming at the disadvantages of cumbersome process, low yields, too many solvents and etc. of synthesis of erythromycin oxime home and abroad, by changing the reaction conditions, selecting the appropriate free agent, optimizing stable reaction system pH, reducing the production of acidic degradation products during reaction process, improving the selective measures of isomers and other measures to find a green synthesis route of erythromycin oxime.
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