In order to solve the problems caused by sugar coating in clinical applications of liver protection tablets , the coating process was changed, the best film coating process was established, and its stability was tested.Sugar coating was switched to film coating, the optimal concentration of the coating liquid, spray rate, and inlet air temperature were determined by orthogonal test, and its stability was tested using accelerated test method and room temperature sample test method.The best conditions of producing film coated tablets were keeping concentration at 13%, spray rate at 140 g/min, and inlet air temperature at 75 ℃. The film coated tablets were passed the stability test in accordance of the Pharmacopoeia of the People's Republic of China （2010 version）.The results showed that the film coating process was stable and suitable for mass production of film coated liver protection tablets.