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| Determination of content of sodium pyrosulfite in phentolamine mesylate injection by UV-VIS Method |
| Wang Wan, Li Yuxin, Chen Hongyu, Wang Xiaofei |
| Hunan Institute for Drug Control, Changsha 410001, China |
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Abstract The absorbance value was measured at 556 nm,and the content was calculated by external standard,. in order to establish UV-VIS method for the determination of content of Na2S2O5 in phentolamine mesylate injection by using UV-VIS method with 0.01 % EDTA solution as solvent,adding 2 mL of 0.05 % basic fuchsin and 3 mL of 0.3% formaldehyde solution,shaking well,color reaction for 20 min. Results showed that Na2S2O5 had good linear relationship within the range of 0.126 96~1.904 4 μg·mL-1 (r=0.999 9), its average recovery rate was 101.01 %, with an RSD of 0.8 % (n=9). The solution was determined within 1 h. Repeatability with good results. The established method is simple, accurate and good exclusivity and suitable for the determination of Na2S2O5 content in phentolamine methylate injection.
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