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| Research on the Synthesis Process of Mirabelon |
| Yang Cangjun |
| Hebei Jiheng Pharmaceutical Corporation Ltd., Hengshui 053400, China |
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Abstract This paper provides a synthesis method of miraberon, using (R) -2- ((4-aminophenethyl) amino) -1-phenyleth-
anol hydrochloride and 2-aminothiazol-4-acetic acid as starting material, EDCI as condensation agent, concentrated hydrochloric acid to provide acidic environment, and ethanol-water as recrystallization solvent. The optimal process conditions are as follows n [(R) -2- ((4-aminophenethyl) amino) -1-phenylethanol hydrochloride]: n (2-aminothiazole-4-
acetic acid) =1:1.2, reaction temperature of 30 ℃, reaction time of 2 h, sodium hydroxide, pH, then recrystallized with 50% ethanol solution, the purity of 99.88% by HPLC test.
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