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| Research on synthesis process of edaravone |
| Ma Ningning， Liu Xiaolian， Yang Cangjun， Han Xiao， Wei Mengmeng， Kang Qian |
| Hebei Jiheng Pharmaceutical Corporation Ltd., Hengshui 053400, China |
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Abstract A method for recrystallization and refinement of edaravone was provided. Industrial grade edaravone is used as starting material, anhydrous ethanol as solvent, activated carbon as decolorizing agent, pharmaceutical grade edaravone finished product was obtained by high temperature dissolution, heat filtration of carbon, and cooling crystallization.The optimal process conditions were as follows: mass ratio of edaravone, anhydrant ethanol and activated carbon was 1: 25: 0.062 5, reaction temperature was 80 ℃, reaction time was 0.5 h, stirring speed was 200 r/min, cooling to was 20 ℃, and edaravone products were obtained by centrifugal drying.During the recrystallization process, the yield of edaravone was 84%. After detection by high performance liquid chromatography, the purity of edaravone product was 99.91%, single impurity was 0.04%, total impurity was 0.09%, which meets the requirements of the Chinese Pharmacopoeia 2020 edition.
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