Four kinds of fluoride-containing wastewater from lead-zinc metallurgy were treated with different processes and different chemicals respectively. The results show that when the dosage of medicament HQF1 is 0.5 kg/m3, the fluorine content in mine water can be reduced from 15.4 mg/L to 1.8 mg/L, and the fluoride removal rate can reach 88.3%; when the dosage of poly aluminum chloride(PAC) is 1700 g/m3, the fluorine content in tailing water can be reduced from 8.4 mg/L to 2.2 mg/L, and the fluoride removal rate can reach 73.8%; when the dosage of HQF1 is 25 kg/m3, the fluoride content can be reduced from 2283 mg/L to 260 mg/L, and the fluoride removal rate can reach 88.6%; when the dosage of medicament A+B is 20 kg/m3, the fluoride content in smetter new solution can be reduced from 171 mg/L to 51 mg/L, and the fluoride removal rate can reach 70.1%.