In the past 20 years, China 's ethylene industry has developed rapidly, from hundreds of thousands of tons to millions of tons. As an important equipment of the separation unit, propylene refrigeration compressor unit and its related equipment and pipeline layout are also facing some problems in the large-scale. This paper attempts to compare some data in past projects to analyze many factors affecting the layout plan, and studies the problems that need to be paid attention to in the layout of pipelines and equipment, in order to obtain some experience that can be used for reference in future projects.