Based on Dongpang Mine threatened by grey water, large volume and high difficulty of water prevention and control, with complicated hydrogeological conditions, in combination with the practical situation of mine, comprehensive geophysical prospecting, drilling, partition wall, grouting water plugging waterproof gate and other measures were adopted in mine water prevention and control. The practice showed that the above method can effectively detect abnormal area actual situation, and use existing drilling through grouting seal transformation anomaly, realized coal mine the partition isolation, narrowing the scope of flood impact, provided a reliable guarantee for coal mine safety production.