In order to provide technical guarantee for the construction and safe mining of Meilinmiao mine field, based on the analysis of the hydrogeological characteristics of each aquifer in the mine, the hydraulic connection of the main aquifer in the mine field was studied by means of field hydrogeological drilling, with pumping and water quality test. The results showed that the hydraulic connection between the Quaternary aquifer and the Cretaceous aquifer in the study area was good; the hydraulic connection between the Cretaceous aquifer and the 3-1 coal seam roof aquifer of the Jurassic system was poor; the hydraulic connection between the 3-1 coal seam roof aquifer of the Jurassic system and the 3~6 coal seam aquifer was poor. At the same time, the mine water inflow would affect the mining of 2-2中 , 3-1中, 6-2中coal seam in the future. The research results could provide a reference for the future hydrogeology and water disaster prevention and control work of the mine, and also had a certain reference value for the mine with similar surrounding conditions.