With the increase of the mining depth of coal mine, the hydrogeological conditions of mine keeps changing.Therefore, it is of great importance to carry out the research on the evaluation of mine hydrogeological conditions.Nanliang Mine was taken as an example in this article, mine comprehensive evaluation and research of the hydrogeological conditions were conducted from the mine main contain ( every ) aquifer group characteristic, mine water inflow water filling conditions, the results provided hydrological geology basis for mine safety in production.