In order to solve sealing leakage and low concentration in coal seam pre-drainage drilling hole sealing of Wangpo Mine, mine gas extraction main drilling hole sealing way was studied and analyzed, combined with the coal seam occurrence and structure, An'erte sealing with pressure was adopted to improve sealing technology. The industrial experiment showed the sealing way improved the sealing quality and ensured the coal seam pre-drainage drilling hole gas concentration, with promoting significance.