Gas is one of the main factors affecting the safe production of coal mines, No.15 coal seam of Xinjing Mine was taken as the research object, combines geological exploration and its production exposure data, from the factors affecting the gas distribution in No.15 coal seam such as geological structure, top and bottom lithology, coal seam burial depth, coal seam thickness, Karst trapped column, etc., and it was found that top and bottom slab lithology and coal seam burial depth were the key factors. The relationship between gas gush and coal seam burial depth was statistically analyzed, and the gas gush was reasonably predicted, and the gas content of No.15 coal seam was 8 ~ 17 m3/t, which was a guiding meaning for the design of gas extraction and other production work at the working face.