Before mining design, the mine field needs to accurately grasp the hydrogeology of coal seam. The 12207 working face of Wangchao Mine was taken as the engineering background, a comprehensive geophysical prospecting method combining 3D seismic method and transient electromagnetic survey method were used to survey the coal seam area of the 12207 working face, and the waterlogged goaf area and fault range and location were determined. The geological conditions such as the stratum and the drilling results of some areas were verified by drilling. The verification results were consistent with the survey results, indicating that the comprehensive geophysical prospecting results were accurate and reliable, which provided safety guarantee for mining design and mining in the mining area.