In order to verify the application performance of the engine lubricant oil for methanol-gasoline, a 12 000 km driving test was carried out. Through the analysis and testing of the anti-oxidation and anti-wear performance of the engine lubricant during the experiment, it was determined that the lubricant had good acid neutralization ability, excellent alkali value retention, anti-friction and anti-oxidation performance, and could meet the requirements of existing vehicles.