In view of the short circuit of ventilation system in the mine ventilation system of Yicheng Mine, a method to reduce the invalid air volume was put forward, shortening the ventilation distance, the closed post mining area and the invalid roadway. The results of the project showed that after the optimization of the ventilation system, the invalid air volume was reduced, the existing problems of the original ventilation system were solved obviously, and the ventilation system of the Yicheng Mine was optimized, which provided a reasonable scheme for other similar mines.