In order to get the accurate and timely ventilation parameters, understand the status of the ventilation system and reduce the mine accident risk, two main line of the mine ventilation system air volume and air pressure, wind resistance and conductance 4 ventilation parameters of Mugua Mine were tested to make a wind network calculating. According to the result of the calculation and the actual situation of the mine, the specific content of the optimization and transformation of the ventilation system was put forward. The practice showed that this method can solve the problems of too much friction resistance, too many places to use the wind, and low operating performance of the return mining, so as to effectively improve the ventilation level of the ventilation system.