In view of the deformation of surrounding rock of mining roadway in Shengxin Coal Mine, taking the 42201 working face of the mine as the engineering background, the roadway excavation model was established by FLAC3D numerical simulation software, and the plastic zone distribution and stress response characteristics of surrounding rock of roadway were studied. The results show that the plastic zone depth of the two sides is smaller than that of the roof and floor of the roadway, and the plastic zone depth of the two sides is controlled within 1 m. The plastic zone width of the roof is the largest, which is 3.5 m, and the plastic zone depth of the floor is about 1 m. Based on the numerical simulation results, the combined support technology of ' diamond metal mesh + steel ladder beam + anchor rod + anchor cable + concrete bottom ' is proposed. The field application results show that the maximum displacement of the roof is 33 mm, and the maximum displacement of the two sides is 18 mm, less than 40 mm, which realizes the effective support for 42201 transport corridor.