Mine gas is a serious threat to the life safety of mine operators, and a ventilator must be installed for ventilation. Xinzhi Mine was taken as an example, an intelligently adjusted fan control system was designed through a PLC industrial controller, and the entire fan system of the mine was optimized. The gas concentration control as the goal, the air supply of the fan was adjusted in real time. Practice showed that the designed intelligent regulating fan system could effectively disperse gas in the underground and improve the equipment utilization efficiency.