Based on the situation that in chemical industry, piston compressor flow regulation overpressure results in the fact that high pressure gas cannot be dredged and that’s leads to serious consequences,according to the characteristics of the piston compressor, combining with an instance of Hebei Jiheng compression, how to flow control of piston compressor through technological measures was interpreted and security measures that used to deal with abnormal condition during the piston compressor technology process were analyzed, so as to provide a reference for compression design.