In order to determine the reasonable layout position of floor roadway under the influence of mining in close distance coal seam group, Xinji No.1 Mine wat taken as the research background, the distribution law of mining stress and plastic zone under different horizontal staggered distances was analyzed by combining numerical simulation with field monitoring. Combined with field engineering data, the optimal roadway layout scheme was put forward. The results showed that when the horizontal stagger distance between No.360808 Face and No.360606 Face was 12 m, the lateral abutment pressure of return airway increased, and the plastic zone was not connected, which was beneficial to the stability of roadway surrounding rock and the stability of roadway was good. The on-site monitoring data showed that there was no obvious roof separation phenomenon in the air roadway of No.360606 Face under the 12 m external distance, which further verified the feasibility of the layout scheme. The research results provided a practical reference for the safe mining of floor roadway in close distance coal seam group mining.