HPLC法测定对乙酰氨基酚杂质含量

doi:10.19286/j.cnki.cci.2022.05.041

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Abstract This paper provides a high-performance liquid phase detection method of acetaminophen dimer impurities in acetaminophen, which can quantitatively analyze the content of the impurity. The detection method is as follows chromatographic column: octane silane bonded silica gel chromatcolumn (250 mm 4.6 mm, 5 m); flow phase: phosphate buffer-methanol (90∶10) as flow phase; flow rate: 1.0 ml/min; column temperature: 40 ℃; sample intake: 20 μl; detection wavelength: 245 nm. The proposed method has a good linear relationship to the acetaminophen impurities, with a relative error of less than 2%.The determination of the impurity content by the HPLC method is simple, fast, accurate and highly sensitive to improve the quality of the acetaminophen products.

Key words： paracetamol paracetamol dimer high performance liquid chromatography

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	Articles by authors
	Zhi Yongqiang
	Liu Xiaolian
	Ma Ningning
	Han Xiao
	Yang Cangjun
	Wang Junkai
	Dai Aiguo
	Hao Xinting

Cite this article:

Zhi Yongqiang,Liu Xiaolian,Ma Ningning等. Determination of paracetamol impurity content by HPLC[J]. CCI, 2022, 45(5): 140-142，148..

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http://www.mtyhg.com.cn/EN/10.19286/j.cnki.cci.2022.05.041 OR http://www.mtyhg.com.cn/EN/Y2022/V45/I5/140

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