In order to meet the drainage needs of the undulating roadway in the coal mine, ensure the personal safety of the underground staff and the smooth mining, according to the conditions of roadway and water gushing in Wantugou Mine, three feasible drainage system schemes were given, and the advantages and disadvantages of each scheme were analyzed through technical analysis, economic analysis and reliability analysis, finally, a reliable and economical drainage system was set for the underground roadway of the mine. The research results showed that the design of drainage system of underground undulating roadway should be determined according to the water inflow situation of roadway, the setting of centralized drainage points and roadway conditions, which can provide reference for the design of drainage system of undulating roadway in mines.