Mine ventilation system is very important to the safe production of coal mines. This article combines the actual conditions of the mine ventilation system in Linxi Mine, through careful inspection of the mine ventilation system, the resistance of mine ventilation was measured, a mine ventilation management information system was set up, with simulation analysis, the mine ventilation system optimization technology research program was given. Through application practice analysis, the mine air volume was increased, and the problems existing in the management of the ventilation system was better solved.