In view of the potential harm to the ecological environment caused by the residue culture medium, a small amount of antibiotics and their degradants contained in the antibiotic fermentation residue, and the large amount of water in the residue makes its quality and volume large, resulting in high treatment cost, a feasible route for reducing antibiotic residue was explored. Through pretreatment of antibiotic bacterial residue and reasonable and economical reduction treatment, excess water was removed, and the reduction reached 90%. After drying, the bacterial residue was granulated to be a good biomass fuel for storage, transportation and treatment. Reduced drying treatment of antibiotic residue not only disposes of waste, but also creates economic benefits.