Venetoclax is a new drug for the treatment of chronic lymphocytic leukemia (CLL). The   synthesis methodS of Venetoclax and the key intermediates ,1-【[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl】piperazine and 3-nitro-4-【[(tetrahydro-2H-pyran-4-yl)methyl]amino】-benzenesulfonamide were summarized.It is proposed a good synthetic route which has high yield and is suitable for industrialized production,but the cost of Pd complex catalyst is expensive, so the cost needs to be cut down.