Oxiracetam is a kind of pyrrolidone derivatives that used for the treatment of brain damage and neurological deficit, impediment of anamnesis and aptitude that caused by brain damage. Aiming at the problems that exist in the synthesis technics of oxiracetam which are too many steps in the synthesis process, too much solid waste, complex operation, and products difficult to purification etc., a new improved method for the synthesis of oxiracetam is proposed, that is ethyl 4-chloroacetoacetate and glycinamide as the raw materials to synthesize oxiracetam. The influences of catalyst, reaction solvent, reaction time on the reaction system were studied. The found best optimum conditions are cyclization reaction pH is 10.5～11.0, the proportion of ethanol water is 1∶8, ratio of glycinamide is 1∶1.0, ratio of the cyclization reaction solvent is 1∶25, cyclization reaction temperature is 77~78℃, the amount of catalyst is 1∶100, and the reaction time is 12 ~ 14 h. The method has the advantages such as raw materials are easy to get, the manufacturing process is simple, high yield, suitable for industrial production and so on.