Major dangerous, harmful factor of coal mine were threat to mine safety production, in many major dangerous, harmful factor influence degree was various on the formation of the accident. In order to determine the influence degree of various factors, make the mine targeted on the major measures provide basis for dangerous and harmful factors, establish evaluation system of major dangerous, harmful factor of coal mine, the evaluation system were studied by using analytic hierarchy process  of each evaluation index weight value size. According to the evaluation results, targeted measures were taken by the mine to ensure safety production.