In chemical production process, hydrogenation reaction is a complex unit process. The factors influencing hydrogenation reaction are temperature, pressure, medium, pH value, catalyst and the contact area of the material. From the production process, the reasons of slow hydrogenation rate and the contact area between the solid, liquid and gas reactants were analyzed, and according to this reason, the agitator type was changed.Using the new type multilayer agitator, the solid, liquid and gas phase could be fully mixed, the contact area of reactants were increased, catalytic capacity was improved, the reaction time was shorted and product yield was improved.