4-溴-2,6-二氟-三氟甲氧基苯的合成工艺研究

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Abstract

A synthetic method of 4- bromo -2,6- two f - three difluoro methoxy benzene was provided using 3,4,5- three fluorine bromine as raw material through substitution reaction, dealkylation reaction, three difluoromethylation reaction, finally the target product 4-bromo -2,6- two fluorine bromine difluoro methoxy - three benzene was got. This method had the characteristics which were the synthetic process was simplified, synthetic technology was reasonable, synthetic steps were shorter, the yield of target product was high, the cost was low, the synthetic process was conducive to large-scale industrial production etc.. Therefore, the synthesis method was suitable for large scale preparation of target compounds.

Key words： liquid crystal intermediate substitution reaction dealkylation reaction three difluoromethylation reaction

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	Articles by authors
	QI Su-zhong
	SHI Jun-jie
	CHEN Ya-peng
	LI Jing

Cite this article:

QI Su-zhong,SHI Jun-jie,CHEN Ya-peng等. Study on Synthetic Process of 4- Bromo -2,6- two f - three Difluoro Methoxy Benzene[J]. CCI, 2013, 36(5): 78-80,124.

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http://www.mtyhg.com.cn/EN/ OR http://www.mtyhg.com.cn/EN/Y2013/V36/I5/78

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