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| Improvement on the Synthesis of 2-（ 5-Amino-1,2,4-thiadiazol-3-yl ）- 2-（ methoxyoimino )a cetic acid |
| CHEN Ying1, SUN Ya-bo1, CHEN Hui1, WEI Shun-jin2, LI Jing1 |
| 1. Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026, China; 2. Hebei Chemical Industry Research Institute,Shijiazhuang 050031,China |
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Abstract The synthesis process of ammonia thiadiazole oxime acetic acid,the fourth-generation cephalosporins key intermediate 7 side chain acid was studied. The variety of catalyst under the condition of different concentrations on the influence of the hydrolysis reaction were examined. The results showed that a suitable hydrolysis catalyst was LiOH, using both oxidant and a phase transfer catalyst could get yield a substantial increase, yield of 80%, purity of 97%, quality was superior to other methods. This process had the chanacteristics of readily available raw materials, simple operation, improving the yield, excellent product quality and being suitable for industrial production.
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