In order to meet the constraints of drilling arrangement to ensure that the pressure chamber is outside the influence range of the pressure relief zone and improve the accuracy of the cross-layer pressure measurement of the cross-cut, taking the corresponding position of the uncovered coal cross-cut and No.17 coal seam in a mine in Guizhou as the prototype, a three-dimensional intuitive geometric model is established and converted into a two-dimensional calculation formula. The Excel editing formula is used to establish a numerical drilling parameter design model. The results of field application analysis show that the maximum absolute error of three-dimensional design is 4.66 m, and the relative error is 6.21 %. The maximum absolute error of the two-dimensional design is 4.38 m, and the relative error is 5.84 %. The maximum design error of the two models is 0.28 m. The two design models can obtain accurate design parameters. The spacing between the two boreholes at the same measuring point is above 20 m, and the pressure chamber is outside the influence range of the pressure relief area. The research provides an efficient and accurate design model for the borehole parameters of the uncovered coal cross-cut.