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Abstract A nonbuxostat synthesis method was provided with 2-(3-aldehyde-4-hydroxyphenyl) -4-methyl-5-ethyl formate thiazole as the starting material, after an isobutylation reaction, cyanogenylation reaction and hydrolysis reaction. The optimal process conditions are as follows: n[2- (3-aldehyde-4-hydroxyphenyl) -4-methyl-5-ethyl methyl thiazole (intermediate 3)]∶ n(1-bromide isobutane)∶ n(K2CO3) = 1∶2.5∶2,90 ℃, reaction 4 h, synthesis 4, synthetic intermediate 4, n (intermediate 4)∶ n (hydroxylamin hydrochloride) =1∶1.85,110 ℃, reaction 4 h intermediate 5, finally 60 ℃ hydrolyzed for 4h in alkaline environment. Fibuxostat yield was 68% overall, with 99.72% pure, 0.09% miscellaneous alone, and 0.28% miscellaneous overall.
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