The manufacturing technologies and the main domestic heparin varieties, which are ordinary heparin and low molecular weight heparin preparations (enoxaparin, heparin, nagchu heparin, tinzaparin, etc.) and the sales data of their domestic and international markets in the past 10 years were summarized and investigated. According to the changing trend of the market of heparin biochemical drugs the future market and varieties were predicted, thus providing scientific data reference for domestic heparin drug manufacturers,and has guiding significance for the production planning and market evaluation.