磺酰脲类除草剂咪唑磺隆及其衍生物的合成

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摘要

以2-氨基吡啶和氯磺酸为原料，首先经氯磺化和氨解反应合成了中间体2-氯咪唑并[1,2-a]吡啶-3-磺酰胺，接着采用胍与β-二羰基化合物缩合合成了5种4,6-位取代和4,5,6-位取代的2-氨基嘧啶化合物，然后磺酰胺与氯甲酸苯酯反应生成磺酰基氨基甲酸苯酯，最后再与2-氨基嘧啶化合物发生加成反应来制备咪唑磺隆及其衍生物（化合物1-5）。采用熔点测定、FTIR、MS和1H NMR等手段分析和确认目标产物的结构。

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	石桂珍
	葛军营
	窦建芝
	张在珍

关键词 ：唑磺隆, 衍生物, 合成

Abstract：

Taking 2-aminopyridine and chlorosulfonic acid as raw material, the intermediate 2-chloroimidazo[1,2-a]pyridine-3-sulfonamide was first synthesized through the reaction of chlorosulfonation and ammonolysis. Then, five kinds of 4,6-substituted and 4,5,6-substituted 2-aminopyrimidine compounds were synthesized through condensation reaction of carbamidine and β-dicarbonyl compounds. Next, sulfonyl carbamic acid benzyl ester was obtained through the reaction of sulfonamide and phenyl chloroformate. At last, through addition reaction of the resulting compound with 2-amino pyrimidine compounds imazosulfuron and its derivates ( compounds 1-5 ) were obtained. The structure of the target products were analyzed and affirmed by melting point, Fourier transform infrared spectra, mass spectra, hydrogen spectra of nuclear magnetic resonance and other methods.

Key words： imazosulfuron derivative synthesis

作者简介: 石桂珍（1980—），女，江苏徐州人，硕士研究生。E-mail: shiguizhen307@163.com

引用本文:

石桂珍，葛军营，窦建芝，张在珍. 磺酰脲类除草剂咪唑磺隆及其衍生物的合成[J]. 煤炭与化工, 2015, 38(6): 43-45，139. SHI Gui-zhen, GE Jun-ying, DOU Jian-zhi, ZHANG Zai-zhen. Synthesis of Sulfonylurea Herbicides Imazosulfuron and Its Derivatives. CCI, 2015, 38(6): 43-45，139.

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http://www.mtyhg.com.cn/CN/ 或 http://www.mtyhg.com.cn/CN/Y2015/V38/I6/43

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