Alkyl glycoside (APG) is one kind of novel and environment friendly surfactant, is synthetized by  natural fatty alcohol and glucose in the presence of acidic catalysts. Because of its virtue of non-ionic surfactant and anionic surfactant, it is widely used in the manufacture of maquillage, detergent, pesticide, packaged food and coating material etc..In the manufacturing process, it has many disadvantages as long reaction time, high product color and polymerization degree.To address these problems, the synthetic technology of alkyl glycoside was investigated. It was found that, to obtain a undertint tinct and low polymerization degree as well as high yield, the optimum reactant ratio and reaction condition should be natural fatty alcohol to glucose 6∶1, catalyst to glucose 0.2∶1, temperature 95 ℃, vacuum degree 95.96 kPa, and particle size 15μm.