Combined with engineering example and grouting seepage-proofing and plugging technology, hydrogeological conditions and seepage reasons of roadway were analyzed, grouting and plugging project design, construction process and technology, water plugging effect, etc were expounded further. The engineering practice showed that grouting seepage-proofing plugging technology was one of the most effective way to control roadway surrounding rock crack leakage, which provided experience for similar seepage-proofing and plugging project.