Cefuroxime axetil tablets were made of cefuroxime axetil, crospovidone, microcrystalline cellulose, hyprolose, silicon dioxide and magnesium stearate, and the prescription process and the dissolution curves in vitro were investigated. Through adopting dry granulation process, designing the orthogonal test and examining the amount of adhesive hyprolose(A), the amount of disintegrants crospovidone(B) and the amount of lubricant magnesium stearate(C), the formulation was screened and the best prescription were A1B2C2. By comparing dissolution curves of four media with the reference formulation, it was found that the three batches of samples had good stability, and  consisted with the dissolution curves of the reference formulation.