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| Research Progress of Polymyxin B |
| WANG Cui-yan, GUO Yue-ling，PENG Liang，ZHONG Wei-tan |
| National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering and Technology Research Center,NCPC New Drug Research and Development Corporation Ltd., Shijiazhuang 050015,China |
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Abstract Polymyxin B is a kind of ten peptide antibiotics produced by fermentation, its clinical application almost stopped from 1970 to 1980 because of its higher toxicity. In recent years,gram-negative bacterial strains with multiple antiboby drug resistance have been found in the intensive care unit,so in the absence of new effective antimicrobial agents against these pathogens,it is necessary to carry out research on polymyxin B.The structure,characteristics,mechanism of action and production methods of polymyxin B were introduced.It was put forward with the establishment of rational drug and further study on the toxicity, polymyxin B will usher in a broader space for development.
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| ［1］ 孟繁珠.沉淀法提取硫酸粘菌素的工艺[ P ]. CN：2012 10244549.6, 2012.［2］ American Cyanamid.Corporation. Method of producing polymyxin[ P ].Canadian: 496083D, 1953.［3］ Distillers Co Yeast Ltd. Polymixin purication[ P ].Canadian: 533410D, 1956.［4］ 佟 斌, 刘桂敏, 吴兆亮, 等. 泡沫分离提取多粘菌素E的工艺研究[ J ]. 食品工业科技，2007，28（5）：153～155.［5］ 杨亚勇，刘珍奇，蒋顺进. 超滤膜在多粘菌素E预处理中的应用[ J ]. 中国抗生素杂志，2001，26（4）：244～245.［6］ Tani T，Shoji H，Guadagni G. Extracorporeal removal of endotoxin: the polymyxin B-immobilized fiber cartridge[ J ]. Contrib Nephrol,2010, (167) : 35 - 44.［7］ Alipour M,Halwani M,Omri A. Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains[ J ]. Int J Pharm, 2008,（355）：293 - 298.［8］ Park S,Chibli H,Wong J. Antimicrobial activity and cellular toxicity of nanoparticle-polymyxin B conjugates[ J ]. Nanotechnology,2011,（22）：185 101. |
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