In response to the problems of difficult support and severe deformation caused by asymmetric distribution of surrounding rock stress and limited bearing capacity of coal pillars in the goaf of thick coal seams with large inclination angles, the goaf roadway of No.35060 Face in Yiluo Mine was taken as the research object. By comprehensively applying theoretical analysis, numerical simulation, and engineering measurement methods, the evolution law of the stress field and deformation and failure characteristics of the surrounding rock in the goaf roadway of inclined coal seams were deeply revealed. Research showed that as the dip angle of the coal seam increased, the concentration of lateral support stress on both sides of the roadway intensified, the peak stress significantly increased, the impact range continued to expand, and the phenomenon of stress imbalance became increasingly prominent. On this basis, a collaborative control scheme with "deep anchoring enhancement, shallow stress optimization, and surface flexible support" as the core was proposed. After numerical simulation and on-site monitoring data verification, the convergence of the roadway roof, floor, and two sides decreased by more than 60% compared to the original support form, effectively improving the overall stability and safety status of the roadway, and providing reference for the design of underground roadway support in coal mines under similar conditions.