高锰酸钾氧化脱色技术在肝素制备中的应用研究

doi:10.19286/j.cnki.cci.2025.07.029

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Abstract

The optimal technical parameters for potassium permanganate oxidation in the extraction and purification of heparin sodium were studied. The amount of potassium permanganate, oxidation temperature, pH vaule and oxidation time were selected for single-factor experiments. Furthermore, orthogonal experiments were used to optimize the decolorization conditions of heparin with potassium permanganate. The quality indicators for oxidized heparin such as decolorization rate, anti-factor IIa activity, yield and weight average molecular weight were investigated, and the structure of disaccharides was analyzed. Results show that the optimal conditions for the oxidation decolorization with potassium permanganate were as follows: the amount of added potassium permanganate was 1.6%, the oxidation temperature was 75 ℃, pH vaule was 9.0, the oxidation time was 4 h. The structure analysis of disaccharides showed that the content of ΔGlyser prepared by oxidation decolorization with potassium permanganate was lower, and the product quality was more stable.

Key words： heparin potassium permanganate oxidation decolorization rate potency weight average molecular weight

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	Articles by authors
	Hu Lina1
	3
	Zhang Hui1
	3
	Zhao Yifan1
	Xu Zhongliang2
	Qie Zhenggang1
	Li Zhimin1
	3

Cite this article:

Hu Lina1,3,Zhang Hui1等. Study on the application of potassium permanganate decolorization technology in the preparation of heparin[J]. CCI, 2025, 48(7): 135-140.

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http://www.mtyhg.com.cn/EN/10.19286/j.cnki.cci.2025.07.029 OR http://www.mtyhg.com.cn/EN/Y2025/V48/I7/135

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