This paper focused on the research of mine water treatment process. Aiming at the problem of iron ion removal, combined with the material field model of TRIZ theory, the three methods of aeration + coagulation + manganese sand filtration were combined to effectively remove iron ions. In view of the removal of suspended solids in mine sewage, combined with the conflict resolution principle of TRIZ theory, the efficient clarification integrated equipment was adopted to effectively improve the flocculation effect. Based on the evolution principle of TRIZ theory, the process flow of mine water comprehensive treatment was formed, and the technical practice was carried out based on the mine water treatment station. The results showed that the suspended solids were completely removed after manganese sand filter and activated carbon filter, and the iron ions were completely removed after ultrafiltration and disinfection, which fully met the requirements of mine water treatment. The effluent of the treatment station could meet the Class III standard of surface water, which could be reused and discharged.