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| Study on controlling butterfly acid content in folic acid |
| Ma Ningning， Liu Xiaolian， Zhang Zhiqiang, Yang Cangjun， Wang Junkai， Han Xiao， Dai Guoai |
| Hebei Jiheng Pharmaceutical Corporation Ltd., Hengshui 053400, China |
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Abstract Folic acid was synthesized from N-(4-aminobenzoyl)-l-glutamic acid, 2,5,6-triamino-4-hydroxypyrimidine sulfate and trichloroacetone. The effects of the amount of dilute sulfuric acid, the concentration of dilute sulfuric acid and the refining time of dilute sulfuric acid on the content of butterfly acid were studied. The results showed that e concentration of dilute sulfuric acid was 10 times of crude folic acid, the concentration of dilute sulfuric acid was 30% , and the time of refining in dilute sulfuric acid solution was 1 hour, the purity of the target compound was 99.5% , and the content of papillary acid was reduced to 0.18% .
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| [ 1 ] 张 龑. 控制蝶酸含量的叶酸的生产方法：中国,CN111196-
812 A[ P ]. 2018 - 11 - 19．
[ 2 ] 梁雪松. 叶酸生产工艺的优化[ D ]. 河北：河北科技大学，2014．
[ 3 ] 侯春燕. 叶酸结晶基础数据测定与结晶过程研究[ D ]. 广州：华南理工大学，2010．
[ 4 ] 柴多里，马云峰. 叶酸的制备及市场前景[ J ]. 化工科技市场， 2001（ 12 ）：19 - 20．
[ 5 ] 郑连义，康怀萍，刘红梅. 叶酸的合成[ J ]. 中国新药杂志，2001，10（ 12 ）：921 - 922．
[ 6 ] 欧洲药典[ S ]. 第9版. |
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