As one of the hidden disaster causing bodies, the collapse column is often formed by the underlying limestone. The collapse column of a certain scale is an important water channel of the mine, and becomes an important factor restricting the automatic mining and safety production of the mine. In order to safely and efficiently predict the spatial distribution characteristics of collapse column in mine field, comprehensive geophysical exploration technology are often used to improve the detection accuracy and accuracy. In this paper, three-dimensional seismic exploration technology and CSAMT technology were used to study the comprehensive detection, data processing and comprehensive interpretation of No 6 mining area in Wutongzhuang coal mine. The results showed that the 3D seismic exploration technology can effectively identify the small structure in the mine, the scale and spatial form of the collapse column. Combined with the detection of CSAMT, the water content of the collapse column were further verified. The comprehensive geophysical exploration technology solved the spatial parameters and water rich state of the collapse column, and provided favorable geological guarantee for the next comprehensive treatment.